CASE 1

1. What are the key points in her history that suggest OA?
   
2. What findings on physical exam support a diagnosis of osteoarthritis? Which findings help distinguish it from an inflammatory arthropathy?
   
3. What features on her hand X-ray are characteristic of hand OA and was the radiograph really necessary in making this diagnosis?
   
4. What laboratory studies are indicated?
   
5. What other therapeutic options could be considered in the future?

CASE 2

1. In this patient with RA, what would be the differential for knee pain and swelling disproportionate to the arthritis activity in the other joints?
   
2. What work-up would best help determine the cause of the knee problems?
   
3. What features of the joint fluid analysis support a diagnosis of OA?
   
4. What features on the knee X-ray are most characteristic of OA?
   
5. What evidenced-based data is there regarding joint injections, oral medications and joint replacement for OA of the knee?